• 姓       名:洪梅
  • 职       称:教授
  • 学       位:博士
  • 所在机构:华南农业大学 生命科学学院
  • 出生年月:
  • 籍       贯:
  • 研究方向:药物转运蛋白的结构-功能关系;药物转运蛋白在兽药吸收、分布和排除(ADME)中的作用及其调控;膜蛋白在对外界环境改变的反应中的信号传导作用
个人简介 学术成果 发表论文

教育背景

1998.09~2003.12 罗格斯大学(Rutgers University) Plant Molecular biology 博士

1992.09~1996.07 中山大学 化学系 学士

工作经历

2009.07-至今 华南农业大学生命科学学院 教授

2007.07-2009.06 哥伦比亚大学医学院辐射研究中心 (Center for Radiological Research, Columbia University Medical Center, New York, NY, USA) 博士后研究科学家

2006.12-2007.06 劳伦斯伯克莱国家实验室生物学分部 (Life science division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA) 访问博士后学者

2003.12-2006.12 罗格斯大学药学院药学系 (Department of Pharmaceutics, College of Pharmacy, Rutgers, The State University of New Jersey, New Jersey, USA) 博士后/助理研究员/副研究员

教授课程

本科生授课:

动物生物化学 (双语授课)

生物化学A(双语授课)

生物化学C

生化与分子生物学专题

生物技术进展

生物专业英语

研究生授课:

生物化学与分子生物学专业英语

生物化学与分子生物学文献综述

生化与分子生物学进展

论文专著

发表论文:

1. Hong W, Wu Z, Fang Z, Huang J, Huang H, Hong M (通讯作者)(2015)Amino Acid Residues in the Putative Transmembrane Domain 11 of Human Organic Anion Transporting Polypeptide 1B1 Dictate Transporter Substrate Binding, Stability, and Trafficking. Mol Pharm. 2015 Nov 20.

2. Hong M (通讯作者), Hong W, Ni C, Huang J, Zhou C.(2015) Protein kinase C affects the internalization and recycling of organic anion transporting polypeptide 1B1. Biochim Biophys Acta. 1848(10 Pt A):2022-2030.

3. Hu W, Xu S, Yao B, Hong M, Wu X, Pei H, Chang L, Ding N, Gao X, Ye C, Wang J, Hei TK, Zhou G.(2014)MiR-663 inhibits radiation-induced bystander effects by targeting TGFB1 in a feedback mode. RNA Biol. 11(9):1189-98.

4. Xiao Y, Deng J, Liu X, Huang J, Sun Y, Dai R, Hong M (通讯作者) (2014) Different binding sites of bovine organic anion-transporting polypeptide1a2 are involved in the transport of different fluoroquinolones. Drug Metab Dispos. 42(8):1261-7.

5. Hong M. (2014) Heavy ion-related bystander effects. Rend. Fis. Acc. Lincei 25(1 supp): 65-68.

6. Hong M.(2014)Critical domains within the sequence of human organic anion transporting polypeptides. Curr Drug Metab. 15(3):265-70.

7. Huang J, Li N, Hong W, Zhan K, Yu X, Huang H, Hong M. (通讯作者)(2013) Conserved tryptophan residues within putative transmembrane domain 6 affect transport function of organic anion transporting polypeptide 1B1. Mol Pharmacol. 84(4):521-7.

8. Zhan K, Yao J, Huang J, Zhou G, Li W, Chen L, Hong M (通讯作者)(2013) Effect of X-ray irradiation on expression of organic anion transporting polypeptides. Int J Radiat Biol. 89(10):832-40.

9. Liu, X, Huang, J, Sun, Y, Zhan, K, Zhang, Z, Hong, M (通讯作者)(2013) Identification of multiple binding sites for substrate transport in bovine organic anion transporting polypeptide 1a2. Drug Metab Dispos, 41(3):602-607.

10. Yu, Y, Liu, X, Zhang, Z, Xiao, Y, Hong, M (通讯作者)(2013) Cloning and functional characterization of the swine (Sus scrofa) organic anion transporting polypeptide 1a2. Xenobiotica. 43(8):738-44.

11. Yao J,Hong, W, Huang, J, Zhan K, Huang H, Hong, M (通讯作者)(2012) N-glycosylation dictates proper processing of organic anion transporting polypeptide 1B1. PLoS One. 7(12): e52563.

12. Li N, Hong W, Huang H, Lu H, Lin G, Hong M(通讯作者) (2012) Identification of amino acids essential for estrone-3-sulfate transport within transmembrane domain 2 of organic anion transporting polypeptide 1B1.PLoS One. 7(5):e36647.

13. Wen G, Hong M (co-first author), Li B, Liao W, Cheng SK, Hu B, Calaf GM, Lu P, Partridge MA, Tong J, Hei TK (2011) Transforming growth factor-β -induced protein (TGFBI) suppresses mesothelioma progression through the Akt/mTOR pathway. Int J Oncol. 39(4):1001-9.

14. Wen G, Partridge MA, Li B, Hong M, Liao W, Cheng SK, Zhao Y, Calaf GM, Liu T, Zhou J, Zhang Z, Hei TK.(2011) TGFBI expression reduces in vitro and in vivo metastatic potential of lung and breast tumor cells. Cancer Lett. 308(1):23-32.

15. Hong, M., Xu, A., Zhou, H., Wu, L., Randers-Pehrson, G, Santella, R, Yu, Z., and Hei, T. K. (2010) Mechanism of Genotoxicity Induced by Targeted Cytoplasmic Irradiation. Brit. J. Cancer. 103(8):1263-8.

16. Hong, M., Li, S.(co-first author), Zhou, F., Xu, W., Du, W., Thomas, P.E., You, G. (2010) Putative Transmembrane Domain 12 of the Human Organic Anion Transporter hOAT1 Determines Transporter Stability and Maturation Efficiency. J. Pharm. Expt. Thera. 332(2):650-8.

17. Wen, G., Hong, M. (co-first author), Patridge, M.A., Li, B., Calaf, G.M., Hei, T.K.(2010) Phosphoproteomic Profiling of Arsenite-exposed Human Small Airway Epithelial Cells. Oncol Rep.23(2):405-12.

18. Zhou, H., Hong, M., Chai, Y., Hei, T.K. (2009) Consequences of cytoplasmic irradiation: Studies from microbeam. J Radiat Res (Tokyo). Suppl A:A59-65.

19. Zhang, Q, Hong, M, Duan, P, Pan, Z, Ma, J, You, G (2008) Organic Anion Transporter OAT1 Undergoes Constitutive and Protein Kinase C-regulated Trafficking through a Dynamin- and Clathrin-dependent Pathway J. Biol Chem. 283(47):32570-9.

20. Wen, G. , Partridge, M.A., Calaf, G.M., Meador, J.A., Hu, B., Echiburu-Chau ,C., Hong, M. and Hei T.K. (2009) Increased susceptibility of human small airway epithelial cells to apoptosis after long term arsenate treatment. Sci Total Environ. 407(3):1174-81. Epub 2008 Oct 31.

21. Hei TK, Zhou H, Ivanov VN, Hong M, Lieberman HB, Brenner DJ, Amundson SA, Geard CR (2008) Mechanism of radiation-induced bystander effects: a unifying model. J Pharm Pharmacol. 60(8):943-50.

22. Hong, M., Zhou, F., Lee, K., You, G. (2007) The putative transmembrane segment 7 of human organic anion transporter hOAT1 dictates transporter substrate binding and stability. J. Pharmacol. Exp. Ther. 320:1209-1215.

23. Hong M, Tanaka K, Pan Z, Ma J, You G. (2007) Determination of the external loops and the cellular orientation of the N- and the C-termini of the human organic anion transporter hOAT1. Biochem. J. 410:515-520.

24. Zhou, F., Hong, M., You, G. (2007) Regulation of human organic anion transporter 4 (hOAT4) by progesterone and protein kinase C in human placental BeWo cells. Am J Physiol Endocrinol Metab. 293(1):E57-61.

25. Hong, M., Xu, W., Yoshida, T., Tanaka, K., Wolff, D.J., Zhou, F, Inouye, M, and You, G. (2005) Human organic anion transporter hOAT1 forms homooligomers. J.Biol. Chem. 280:32285-32290.

26. Zhou, F., Xu, W., Hong, M., Pan, Z., Sinko, P.J., Ma, J., You, G. (2005) The role of N-linked glycosylation in protein folding, membrane targeting, and substrate binding of human organic anion transporter hOAT4. Mol Pharmacol. 67:868-76.

27. Hong, M., Zhou, F. and You, G. (2004) Critical amino acid residues in transmembrane domain 1 of the human organic anion transporter hOAT1. J. Biol. Chem. 279:31478-31482.

28. Hong, M., Zilinskas, B.A., Knipple, D.C. and Chin, C.K. (2004) Cis-3-hexenal production in tobacco is stimulated by 16-carbon monounsaturated fatty acids. Phytochem. 65:159-168.