• 姓       名:文继开
  • 职       称:教授
  • 学       位:博士
  • 所在机构:华南农业大学 生命科学学院
  • 出生年月: 1977年07月
  • 籍       贯:
  • 研究方向:动物病原与宿主细胞的相互作用;真核生物细胞RNA对细胞的重要生物过程的影响
个人简介 学术成果 发表论文

教育背景

2005.10-2010.01 伯明翰大学  细胞生物学 博士

1999.08-2002-07 中国科学院武汉病毒研究所 生物化学与分子生物学 硕士

1995.09-1999.07 湖北大学 生物技术 学士

工作经历

2014.01- 华南农业大学生命科学学院 教授

2010.06-2013.12 伯明翰大学生物系 Research Fellow

2009.11-2010.05 伯明翰大学生物系 Research Assistant

2002.08-2005.10 中国科学院武汉病毒研究所 助理研究员

论文专著

1.K.-Jubran1, J. Wen1, S. R. Chaudhury, M. Li, A. Abdullahi, P. Ramanathan, K. Piechoki, K. N. Rugjee and S. Brogna . (2013) Visualization of the Assembly of 80S Ribosomes Reveals the Presence of Functional Ribosomes in the Nucleus. RNA 19(12) 1669-83.

2.K. N. Rugjee, S. R. Chaudhury, K. A. Jubran, P. Ramanathan, T. Matina, J. Wen and S. Brogna (2013). Fluorescent protein tagging confirms the presence of ribosomal proteins at Drosophila polytene chromosomes.

3.Li Z, Wen J, Lin Y, Wang S, Xue P, et al. (2011) A Sir2-Like Protein Participates in Mycobacterial NHEJ. PLoS ONE 6(5): e20045.

4.Wen, J., and Brogna. S. (2010) Splicing-dependent NMD does not require the EJC in Schizosaccharomyces pombe. EMBO Journal 29(9) 1537-1551.

5.Brogna, S., and Wen, J. (2009). Nonsense-mediated mRNA decay (NMD) mechanisms (Perspective). Nat Struct Mol Biol 16, 107-13.

6.Bonander, N., Darby, R.A., Grgic, L., Bora, N., Wen, J., Brogna, S., Poyner, D.R., O' Neill, M.A., and Bill, R.M. (2009). Altering the ribosomal subunit ratio in yeast maximizes recombinant protein yield. Microb Cell Fact 8, 10.

7.Li, F., Zhang, Z., Peng, J., Cui, Z., Pang, D., Li, K., Wei, H., Zhou, Y., Wen, J., and Zhang, X. (2009). Imaging viral behavior in Mammalian cells with self-assembled capsid-quantum-dot hybrid particles. Small 5, 718-26.

8.Li, N., Cui, Z., Wen, J., Zhang, Z., Wei, H., Zhou, Y., and Zhang, X. (2008). Live cell imaging of protein interactions in poliovirus RNA replication complex using fluorescence resonance energy transfer (FRET).Biochem Biophys Res Commun 368, 489-94.

9.Brogna, S., Ramanathan, P., and Wen, J. (2008). UPF1 P-body localization. Biochem Soc Trans 36, 698-700.

10.Wen, J., and Brogna, S. (2008). Nonsense-mediated mRNA decay. Biochem Soc Trans 36, 514-6.

11.Guo, Y., Zhou, Y., Zhang, X., Zhang, Z., Qiao, Y., Bi, L., Wen, J., Liang, M., and Zhang, J. (2006). Phage display mediated immuno-PCR. Nucleic Acids Res 34, e62.

12.Zhang, J., Zhang, X., Zhou, Y., Bi, L., Zhang, Z., Wang, S., Chen, Y., Guo, Y., Wen, J., and Yu, Z. (2007), Construction and Characterization of an Anti-Prion scFv Fusion Protein Pair for Detection of Prion Protein on Antibody Chip, Analytical Letters, 40:5, 855 – 873.

13.You, F., Zhou, Y., Zhang, X., Huang, Z., Bi, L., Zhang, Z., Wen, J., Chen, Y., Jiang, G., and Zheng, M. (2006). Cell-free bioassay for measurement of dioxins based on fluorescence enhancement of fluorescein isothiocyanate-labeled DNA probe. Anal Chem 78, 7138-44.

14.Cui, Z., Zhang, Z., Zhang, X., Wen, J., Zhou, Y., and Xie, W. (2005). Visualizing the dynamic behavior of poliovirus plus-strand RNA in living host cells. Nucleic Acids Res 33, 3245-52.

15.Wen, J., Zhang, X., Cheng, Z., Liu, H., Zhou, Y., Zhang, Z., Yang, J., and Deng, J. (2004). A visual DNA chip for simultaneous detection of hepatitis B virus, hepatitis C virus and human immunodeficiency virus type-1. Biosens Bioelectron 19, 685-92.

16.Wang, S., Wen, J., Zhou, Y., Zhang, Z., Yang, R., Zhang, J., Chen, J., and Zhang, X. (2004). Identification and characterization of Bacillus anthracis by multiplex PCR on DNA chip. Biosens Bioelectron 20, 807-13.

17.Wen, J., Zhang, X., Zhou, Y., Wang, J., Zhang, Z. and Zhang, X. (2003). A Genotype 3, Subtype 3b of Hepatitis C Virus Found in Wuhanby Using Gene Chip. Chinese Journal of Virology 19, 274-7. (In Chinese, English Abstract available)

专利成果

一种基因芯片上的酶标信号检测方法,专利号:ZL 02 1 15833.9,发明人:张先恩,邓教宇,黄旭,张治平,邵文海,文继开,陆红兵,刘强。