• 姓       名:张玲华
  • 职       称:教授
  • 学       位:博士
  • 所在机构:华南农业大学 生命科学学院
  • 出生年月: 1978年01月
  • 籍       贯:浙江省宁波市
  • 研究方向:微生物;免疫学
个人简介 学术成果 发表论文
广东省千百十培养对象

教育背景

1997年4月于华南理工大学毕业

2004年在华南理工大学攻读博士学位,于2007年毕业于华南理工大学生物工程与科学学院微生物工程

工作经历

在广东省农科院生物技术研究所一直从事免疫及微生物学的研究与相关产品的开发,

于2005年作为引进人才调入华南农业大学生命科学院从事免疫及微生物教学与科研工作。

学术兼职

被《Vaccine》(Impact factor, 3.159)、《International Immunopharmacology》(Impact factor, 2.157)、《Scandinavian Journal of Immunology》(Impact factor, 2.090)、《Indian Journal of Medical Research》(Impact factor, 1.224)等杂志社邀请为审稿人(Reviewer)。兼任广东省科技咨询专家、教育部“博士后基金”评审专家等。

科研项目

(1)广东省自然科学基金自由申请项目,HPS感染细胞模型的建立及新型Sup ODN抗HPS感染机制研究、 2015/01-2017/12、10万元、主持。

(2)2012.1-2013.12 主持广东省教育部产学研结合项目“分泌型毕赤酵母发酵制备饲用抗菌肽 PR39 的研究及应用”( 30万元,NO:2011B090300020,进展顺利)

(3)2011.1-2013.12 主持国家自然科学基金“CpG ODN 通过NF-κB 信号系统延缓T 细胞衰老的分子机制”(34万元,NO:31072114,进展顺利)

(4)2010.1-2012.12 主持广州市重点科技项目“抗仔猪断奶应激腹泻CpG制剂关键技术研究及示范”(15万元,NO: 2010Z1-E311,进展顺利)

(5)2009.9-2012.9 主持广东省农业攻关项目“幼猪高热病疫苗免疫增效剂CpG的研究及应用 ”(5万元,NO: 2009B020307010 ,进展顺利)

(6)2008.8-2010.12 主持美国Merial合作项目“CpG仔猪抗病免疫机理研究”(24万元,已完成)

(7)2008.1-2010.12 主持广州市重点科技项目“高效功能型硝酸盐降解菌群的构建及其制剂的生产和应用”,(12万元,NO:2008-Z1-E081,已完成)

(8)2007.10-2008.9 主持美国Merial合作项目“CpG诱导仔猪先天性免疫能力”(51.3万元,已完成)

(9)2006.9-2009.8 主持广东省农业攻关项目“高效硝酸盐降解功能菌群的构建及应用”(6万元,NO: 2006B20601011,已完成)

论文专著

2006年至今已在Vaccine、 Molecular Immunology、Developmental and Comparative Immunology等国际知名期刊发表20余篇论文,累积影响因子48.998。

近期发表与本项目相关的科技论文

(1)Yang, J., Lu, Z.P., Chen, J.W., Chu, P.P., Cheng, Q.M., Liu, J., Ming, F.P., Huang, C.Y., Xiao, A.J., Cai, H.M., Zhang, L.H. (张玲华)*. (2016) Effect of cooperation of chaperones and gene dosage on the expression of porcine PGLYRP-1 in Pichia pastoris. Applied Microbiology and Biotechnology, DOI 10.1007/s00253-016-7372-4. (* 通讯作者, 2015 SCI Impact factor, 3.811)

(2)Cai, H.M., Kuang Z.S., Huang K.Y., Shi, J.Q., Zhao X.J., Chu, P.P., Huang, C.Y., Ming, F.P., Xia, F.G., Yang, J., Zhang, L.H. (张玲华)*. (2014) CpG oligodeoxynucleotide protect neonatal piglets from challenge with the enterotoxigenic E. coli , Veterinary Immunology and Immunopathology, 161, 66–76 (* 通讯作者2013 SCI Impact factor, 1.782)

(3)Yang, J., Mao, M.P., Huang Z.F., Zhang, S.Q., Chen, S.F., Li, H.Z., Jiang, Z.G., Cao, G.J., Cao, D., Wang, X.F., Zhang, L.H. *(张玲华). (2012) Innate defence regulator peptide synergizes with CpG ODN for enhanced innate instestinal immune responses in neonate piglets. Int. Immunopharmacol. 12(2), 415–424 (*通讯作者,2010 SCI Impact factor, 2.325)

(4)Cao, D., Li, H.Z., Jiang, Z.G, Cheng, Q., Yang, Z.H., Xu, C.C., Cao, G.J., Zhang, L.H. *(张玲华). (2011) CpG oligodeoxynucleotide synergizes innate defense regulator peptide for enhancing the systemic and mucosal immune responses to pseudorabies attenuated virus vaccine in piglets in vivo. Int. Immunopharmacol. 11, 748–754 (*通讯作者,2010 SCI Impact factor, 2.325)

(3) Cao, D., Li, H.Z., Jiang, Z.G, Xu, C.C., Cheng, Q., Yang, Z.H., Cao, G.J., Zhang, L.H. *(张玲华). (2010) Synthetic innate defence regulator peptide enhances in vivo immunostimulatory effects of CpG-ODN in newborn piglets. Vaccine. 28, 6006–6013. (*通讯作者,2009 SCI Impact factor, 3.616)

(4)Cheng, Q., Xu, C.C., Zhang, L.H. *(张玲华), Li, J.Q., Cao, T., Zhang, M.R. (2010) Administered CpG Oligodeoxynucleotide Induces mRNA expression of CXC and CC Chemokines at the Intestinal Mucosa and PBMCs in Piglets. Int. Immunopharmacol. 10, 611-618 (*通讯作者, 2009 SCI Impact factor, 2.214)

(5)Cheng, Q., Jiang, Z.G., Xu, C.C., Li, H.Z., Cao, D., Yang, Z.H., Cao, G.J., Zhang, L.H. (张玲华)*(2010) CpG oligodeoxynucleotide promotes protective immunity in the enteric mucosa and suppresses enterotoxigenic E. coli in the weaning piglets. Int. Immunopharmacol. 10, 1249–1260 (*通讯作者, 2009 SCI Impact factor, 2.214)

(6) Zhang, L.H. *(张玲华), Tian, X.S., Zhou, F.Z. (2008a) In vivo oral administration effects of various oligodeoxynucleotides containing synthetic immunostimulatory motifs in the immune response to pseudorabies attenuated virus vaccine in newborn piglets. Vaccine. 26, 224-233. (*通讯作者,2007 SCI Impact factor, 3.377)

(7) Zhang, L.H.(张玲华), Zhang, M.R., Li, J.Q., Cao, T., Tian, X.S., Zhou, F.Z. (2008b) Enhancement of mucosal immune responses by intranasal co-delivery of Newcastle disease vaccine plus CpG oligonucleotide in SPF chickens in vivo. Research in Veterinary Science. 85, 495–502. (2007 SCI Impact factor, 1.274)

(8)Zhang, L.H. *(张玲华), Tian, X.S., Zhou, F.Z. (2007a) In vivo immunostimulatory effects of CpG ODN in newborn piglets. Molecular Immunology. 44, 1238–1244. (*通讯作者,2006 SCI Impact factor, 4.768)

(9)Zhang, L.H. *(张玲华), Tian, X.S., Zhou, F.Z. (2007b) In vivo effects of oligodeoxynucleotides containing synthetic immunostimulatory motifs in the immune response to swine streptococcic septicemia vaccine in weaned piglets. Molecular Immunology. 44, 1141–1149. (*通讯作者,2006 SCI Impact factor, 4.768)

(10)Zhang, L.H. *(张玲华), Tian, X.S., Zhou, F.Z. (2007c) Vaccination with porcine reproductive and respiratory syndrome killed virus vaccine and immunostimulatory oligodeoxynucleotides induces specific immunity in piglets. Vaccine. 25, 1735–1742. (*通讯作者,2006 SCI Impact factor, 3.159)

(11)Zhang, L.H. *(张玲华), Tian, X.S., Zhou, F.Z. (2007d) Vaccination with Newcastle disease vaccine and CpG oligodeoxynucleotides induces specific immunity and protection against Newcastle disease virus in SPF chicken. Veterinary Immunology and Immunopathology. 115, 216–222. (*通讯作者,2006 SCI Impact factor, 1.994)

(12)Zhang, L.H. *(张玲华), Tian, X.S., Zhou, F.Z. (2007e) Intranasal administration of CpG oligonucleotides induces mucosal and systemic Type 1 immune responses and adjuvant activity to porcine reproductive and respiratory syndrome killed virus vaccine in piglets in vivo. International Immunopharmacology. 7(13), 1732–1740. (*通讯作者, 2006 SCI Impact factor, 2.157)

(13)Zhang, L.H.(张玲华), Tian, X.S., Zhou, F.Z. (2007f) CpG oligodeoxynucleotides augment the immune responses of piglets to swine Pasteurella multocida living vaccine in vivo. Research in Veterinary Science. 83(2),171-181. (2006 SCI Impact factor, 1.258)

(14)Zhang, L.H. *(张玲华), Guo, Y., Tian, X.S., Zhou, F.Z. (2006a) Co-administration of porcine-specific CpG oligodeoxynucleotide enhances the immune responses to pseudorabies attenuated virus vaccine in newborn piglets in vivo. Developmental and Comparative Immunology. 30(6), 589-596. (*通讯作者,2005 SCI Impact factor, 3.261)

(15)Zhang, L.H. *(张玲华), Tian, X.S., Guo, Y., Zhou, F.Z. (2006b) Effects of CpG ODN on CD4+ and CD8+ T subpopulations in the immune response to porcine reproductive and respiratory syndrome killed virus vaccine. Vaccine. 24(11), 1874-1879 . (*通讯作者,2005 SCI Impact factor, 2.822)

(16)Zhang, L.H. *(张玲华), Tian, X.S., Zhou, F.Z. (2006c) The efficacy of CpG oligodinucleotides, in combination with conventional adjuvants, as immunological adjuvants to swine streptococcic septicemia vaccine in piglets in vivo. International Immunopharmacology. 6(8), 1267-1276. (*通讯作者,2005 SCI Impact factor, 2.008)

(17)Zhang, L.H. *(张玲华), Tian, X.S., Zhou, F.Z. (2006d) In vivo effects of oligodeoxynucleotides containing synthetic immunostimulatory motifs in weaned piglets. International Immunopharmacology. 6(10),1623-1631. (*通讯作者,2005 SCI Impact factor, 2.008)

(18)Zhang, L.H. *(张玲华), Guo, Y., Tian, X.S., Zhou, F.Z. (2006e) CpG oligodinucleotides induce strong humoral and cellular responses to swine streptococcic septicemia vaccine in piglets in vivo. International Immunopharmacology. 6(3), 342-350. (*通讯作者,2005 SCI Impact factor, 2.008)

(19)Zhang, L.H.(张玲华), Tian, X.S., Guo, Y., Zhou, F.Z. (2006f) The effect of transgenic expression of porcine interleukin-6 gene and CpG sequences on immune responses of the newborn piglets inoculated with pseudorabies attenuated vaccine. Research in Veterinary Science. 80, 281-286. (2005 SCI Impact factor, 1.106)

专利成果

(1)张玲华,田兴山,邝哲师,陈薇,李健雄,有益微生物制剂稳定化预处理工艺,2006.12,中国,ZL200310117512.8

(2)邝哲师,田兴山,张玲华,陈薇,李健雄,“有益微生物制剂稳定化后处理工艺”, 2006.8,中国, ZL200310117511.3

(3)邝哲师,张玲华,徐志宏,“一种微生物转化菠萝渣为生物饲料的制备方法”, 2008.1,中国, ZL200610033024.2

(4)张玲华,李华周,姜增固。“一种高效CpG制剂及其制备方法和应用”, 2014.6,中国,ZL201210090979.7

(5)张玲华,明飞平,邝哲师,黄魁英,叶明强,赵祥杰,杨军,夏枫耿,赵培静,黄乐天、蓝碧锋、曹丁。“一种利用氧载体促进毕赤酵母高密度发酵的方法”,专利号:201310271420.9

(6)张玲华,邝哲师,蔡海明,赵祥杰,楚品品,叶明强,“一种高效提高枯草芽孢杆菌出芽率的方法”,专利号:201410162370.5

(7)张玲华,蔡海明,马苗鹏,周洁安,“一种高效抗炎性PB ODN序列及其应用”,专利号:20151043403.5

(8)张玲华,马苗鹏,杨军,“一种嗜酸乳酸杆菌与醋酸杆菌混合发酵的方法”,专利号:201510335715.7

(9)江学斌,张玲华,胡位荣,马苗鹏,黄瀚威,“一种高效降低水体COD沼泽红假单胞菌的培养基”专利号:201610026084.5

奖励/荣誉

获省级科学技术奖二等奖1项(第二完成人)、广东省农科院科学技术奖二等奖1项(第二完成人)、茂名市科学技术奖三等奖1项(第三完成人)

1、田兴山,张玲华,石和荣,邝哲师,李健雄,柯浩,潘木水,唐小俊,马江耀,陈薇,黄晓光,谢海燕,周风珍,李国立,孙晓刚。“有益微生物制剂促进动物生长的研究及应用” 通过省科技厅成果鉴定,总体达国内领先水平,部份技术达到国际领先水平,2004年获广东省科技进步二等奖。

2、田兴山, 石和荣,张玲华,张彪,邝哲师,唐小俊,柯 浩,李健雄,马江耀,周风珍,陈薇。 “对虾生态养殖技术研究及应用”, 2004年度获得茂名市科技进步三等奖。